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Only overnight bus issue is sometimes it's to short. Without traffic at night that bus can take 6 hours so make sure you don't leave to early. Stay at Macondo Hostel.
Over night bus is good as long as your hostel will let you in if you get there very early. I arrived late from Villa De Leyva to San Gil and just got a taxi to our hostel and was fine. But we walked around on outskirts of the city in the day time and one area felt bit sketchy.